The Institute for Biomedical Aging Research serves as a contact for all questions related to aging research. The Austrian Academy’s decision to establish an Institute for Biomedical Aging Research was part of its strategy to establish a program encompassing the widely divergent projects on aging research being conducted in scattered groups around the country. The Cell Metabolism and Differentiation Research Group (Head Werner Zwerschke) has a strong focus on Cancer Research.

INCA Project

Under INCA, we want to investigate the interaction of HPV-16 E7 with cellular ubiquitin E3 ligases. Moreover, we will develop peptide aptamers inhibiting the KSHV LANA-1 protein.

Fiedler, M., Müller-Holzner, E., Viertler, H. P., Widschwendtner, A., Laich, A., Pfister, G., Spoden G. A., Jansen-Dürr, P. & W. Zwerschke. (2004) High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies. FASEB J. 18:1120-2. Fiedler, M., Ressler, S., Campo-Fernández, B., Laich, L., Jansen, L., Widschwendter, A., Viertler, H.P., Bacher, N., Morandell, D., Müller-Holzner, E., Dürst, M., Jansen-Dürr, P. and W. Zwerschke (2005) Expression of the high-risk human papillomaviruses type-18 and -45 E7 oncoproteins in cervical carcinoma biopsies. J Gen Virol. 86:3235-3241. Santer, F., Bacher, N., Moser, B., Morandell, D., Ressler, S., Firth, S. M., Spoden, G. A., Sergi, C., Baxter, R. C., Jansen-Dürr, P. and W. Zwerschke. (2006) Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis. Cancer Research 66:1-10. Fiedler, M., Campo-Fernández, B., Laich, A., Moser, B., Stöckl, P., Jansen-Dürr, P. and W. Zwerschke. (2006) Purification and characterization of the E7 oncoproteins of the high-risk human papillomavirus types 16 and 18. J. Virol. Methods 134:30-35. Campo-Fernandez B, Morandell D, Santer FR, Zwerschke W, Jansen-Durr P. (2006) Identification of the FHL2 transcriptional coactivator as a new functional target of the E7 oncoprotein of HPV-16. J Virol. Nov 8; 2006 [Epub ahead of print]